ea0029p571 | Diabetes | ICEECE2012
Hayashi Y
, Tanaka H
, Sanzen N
, Sekiguchi K
, Murata Y
Introduction: Islets of Langerhans are well innervated and vascularized, however, the regulatory mechanisms for innervation and vascularization are not well clarified. In mice deficient for proglucagon-derived peptides (Gcggfp/gfp: GCGKO), islet cells that express green fluorescent protein (GFP) under the control of glucagon promoter (α-cells) display hyperplasia and number of islets is increased. The present study was aimed to clarify role of the proglu...